Abstract
A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Humans
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Isoenzymes / antagonists & inhibitors
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Phosphodiesterase 4 Inhibitors*
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Phosphodiesterase Inhibitors / chemistry*
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Phosphodiesterase Inhibitors / pharmacology*
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Structure-Activity Relationship
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Thiadiazines / chemistry*
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Thiadiazines / pharmacology*
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Triazoles / chemistry
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Triazoles / pharmacology*
Substances
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Isoenzymes
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Phosphodiesterase 4 Inhibitors
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Phosphodiesterase Inhibitors
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Thiadiazines
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Triazoles